Design is incredibly subjective and each person has their own opinions and interpretations. To ensure your vision is realized you can implement interface prototyping to visually display thousands of words worth of design and development requirements regarding how a system should both look and behave.
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Out of the box, Sitefinity comes with its own grid system that can be utilized to build the layout of your site or app. You can even use media queries in your theme CSS to mold this grid system into being responsive, if you want. Going this route is tricky though, and your media queries will quickly start to grow, become messy, and you’ll probably run into CSS inheritance issues that could break your layout in unwanted ways.
There is a better way that will solve your own interface development headaches and also provide ease of use for your Sitefinity end user to add layouts that are responsive. They are called Layout Widgets – essentially .ascx file that define the HTML of your responsive grid. You can have as many as you want and they are easy to add to your project via the Toolbox.